The 38-year-old comedian is a week into the process, and she's calling on her followers for advice and support.
In May 2019, Schumer welcomed a baby boy named Gene with her husband Chris Fischer. Almost a year later, it seems that the happy couple is ready for another child.
"I’m a week into IVF and feeling really run down and emotional," Schumer shared in her post.
"If anyone went through it and if you have any advice or wouldn’t mind sharing your experience with me please do. My number is in my bio. We are freezing my eggs and figuring out what to do to give Gene a sibling."
View this post on Instagram
I’m a week into IVF and feeling really run down and emotional. If anyone went through it and if you have any advice or wouldn’t mind sharing your experience with me please do. My number is in my bio. We are freezing my eggs and figuring out what to do to give Gene a sibling. ❤️
The photo features Schumer's bruised stomach, likely as a result of IVF-related injections.
Upon posting, support rolled in from a number of expectant mothers, women struggling with subfertility and a myriad of celebrities such as Selena Gomez, Tess Holliday, and Katie Couric.
"I appreciate you as a mother, a woman, a public figure, your vulnerability is so powerful," Holliday wrote.
The number in Schumer's bio will lead you to Community, a platform that's been used by an increasing amount of celebrities.
Community is a tech company in Los Angeles that has raised $35 million to help corporations, stars and other high-profile clients manage direct messaging with a mass audience.
The app has yet to complete a public launch and is in the process of onboarding both companies and celebrities.
Text the number, and you're asked to sign up for Community, then promised that "from here on out, it's all me personally."
Schumer has used it before to touch base with her fans.
The comedian has also spoken about fertility at length before this. When pregnant with her first child, she took to Instagram about her decision to cancel the remainder of her tour due to hyperemesis gravidarum, a pregnancy complication that causes severe nausea and vomiting.
Schumer's first birth with Gene led to a three-hour C-section.
"I was throwing up through the first hour of my c-section. It’s supposed to take about an hour and a half — mine took over three hours because of my endometriosis,” Schumer revealed on an episode of the Informed Pregnancy and Parenting Podcast, “and that was really scary."
Main image by @amyschumer